The anthranilic diamides constitute a new class of crop protection agents, active against phytophagous insects. They are activators of the ryanodine receptors (RyR) which are ubiquitous Ca channels that regulate the Ca release from intracellular stores located in the sarcoplasmic reticulum. The diamides have excellent toxicity and ecotoxicity profiles due to specific interaction with insect RyR.   The commercial anthranilic diamide insecticide Rynaxypyr has a broad spectrum of insecticidal activity against lepidopteran and coleopteran pests at very low concentrations. In an effort to further increase the potency and enlarge the spectrum of activity, mainly against hemipteran pests, we were interested in exploring anthranilic diamides with bicyclic heterocyclic scaffolds. This poster will present syntheses of various novel bicyclic anthranilic diamides like 1  and 2 , and structure activity relationships for their insecticidal activity.

Heterocyclic anthranilic diamides as modern insecticides

248th National Meeting (2014)

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