Modern insect control demands innovative new insecticides. This in mainly due to the development of resistance to current treatments, newly evolving pest problems and the changing regulatory landscape and market environment. Recent research at Hunan Research Institute of Chemical Industry has resulted in the discovery of a new class of insecticides, the dichloropropenes containing a nitro group. The dichloropropenes are active against a wide range of pests. Only one member of this group, 2,6-dichloro-4-(3,3-dichloroallyoxy)phenyl-3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether (S-1812), has already been developed as an agricultural insecticide under the trade name 'Pyridalyl' by Sumitomo Chemical Co Ltd., Japan. Our work resulted in the identification of dichloropropenes containing nitro groups, these compounds especially one member (HNPC-A12278) give very good control of various lepidopterous and thysanopterous pests on vegetables without phytotoxicity. The insecticidal potency of A12278 is comparable to Pyridalyl and it also produces unique insecticidal symptoms. This presentation will describe the discovery, synthesis, biological activity and structure-activity relationships of dichloropropenes containing nitro groups. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/241nm/uploads/62853_slide1cropped.jpg' alt='' />

Recent developments in the chemistry of dichloropropenes

248th National Meeting (2014)

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