Magnetic resonance imaging (MRI) has become a predominant means of diagnosing diseases in the medical field. However, there are several limitations to conventional contrast agents, two major concerns being low number of coordinated water molecules and a large tumbling rate. The Raymond group has synthesized a hexadentate ligand that addresses both of these limitations. The ligand contains three hydroxypyridinone (HOPO) rings that are capped by Tris(2-aminoethyl)amine (TREN) and conjugated to a gold nanoparticle via thiol linking motifs. This ligand has more coordination sites available for water to interact without compromising the strength of the chelator, while reducing the tumbling rate through conjugation with the gold nanoparticle. The Gd(III)-TREN-tris-(6-Me)-3,2-HOPO complex has the potential to reduce the amount of contrast agent necessary to attain a high contrast image, and because of the versatility and inertness of gold nanoparticles, it can be further modified to target and image a variety of afflictions.? ?

Synthesis of Gd(III)-TREN-tris-(6-Me)-3,2-HOPO complex: Applications in MRI

248th National Meeting (2014)

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