Poly(2-alkyl-2-oxazolines) have attracted much attention recently. We are interested in exploiting poly(2-oxazoline)s in novel applications particularly in the context of cellular engineering. We report here the development of biologically compatible poly(2-alkyl-2-oxazoline) materials.We have synthesised different poly(2-alkyl-2-oxazoline) coated cell substrates. These surfaces have been characterised using two types of cell (human bronchial epithelial cells (16HBE) and human fetal lung fibroblast cells (MRC5)). By comparing their adhesion and growth behaviour we have developed a procedure which allows one of our studied cell types to be preferentially grown from a mixture of the two.We also report the development of poly(2-oxazoline) thermogelling polymers. These consist of a polar carboxymethylcellulose backbone, supporting poly(2-oxazoline) 'arms' which reversibly link the gel together. These materials reversibly gel within a temperature region suitable for biological applications. We have then used this material to support multi-layered cell sheet production. This allows cells of different type to be grown and layered on top of one another.

Poly(2-oxazoline)s: Designing useful materials for cellular engineering applications

248th National Meeting (2014)

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