An improved and scalable process for the transformation of glucose to 2-C-methyl-D-ribono-1,4-lactone was developed and demonstrated on 500-g scale.Compared to previous processes for the synthesis of 2-C-methyl-D-ribono-1,4-lactone, improvements include isolation of the intermediate as a pure solid; use of reagents in catalytic instead of superstoichiometric quantities; reduction in total reaction time; a simplified work-up process; and the ability to monitor the reaction progress by UV-HPLC.

Improved synthesis and isolation of 2-<i>C</i>-methyl-<i>D</i>-ribono-1,4-lactone

248th National Meeting (2014)

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Improved synthesis and isolation of 2-C-methyl-D-ribono-1,4-lactone