Herein we describe approaches to modify RNA in cells by using small molecules.  Examples described include: (i) the use of alkylation chemistry to allow for the formation of small molecule-RNA covalent bonds, and (ii) the use of photochemistry to produce hydroxyl radicals that allow for the targeted destruction of disease-associated RNAs.  The ability to react and modify RNAs with small molecule in cells could have utility in RNA chemical biology as targeting validation tools and to manipulate RNA function.

Use of small molecules to modify RNA <i>in cellulo</i>

248th National Meeting (2014)

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Use of small molecules to modify RNA in cellulo