An efficient reaction manifold for the preparation of C3/C5-diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C�H functionalization event.

Sequential C3 and C5 direct C�H arylation of imidazo[1,2-<i>a</i>]pyrazines with (hetero)aryl bromides

248th National Meeting (2014)

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Sequential C3 and C5 direct C�H arylation of imidazo[1,2-a]pyrazines with (hetero)aryl bromides