The aim of the present work was to construct prochloraz-loaded mPEG-PLGA particles with different sizes (from nanoscale to microscale) and to study the size-dependent effect on vitro prochloraz release and germicidal efficacy. The desirable mPEG-PLGA copolymer was selected. Prochloraz-loaded mPEG-PLGA particles with different sizes were constructed by emulsion/solvent evaporation method. The size and its distribution, stability, prochloraz loading content (LC), prochloraz release behavior, and germicidal efficacy of prochloraz-loaded particles were investigated. Prochloraz-loaded mPEG-PLGA particles with different sizes were successfully constructed. The prochloraz-loaded mPEG-PLGA particles all showed a sustained release process. As the size of the prochloraz-loaded particles became large, the LC value increased, and prochloraz released in low speed. All of the prochloraz -loaded particles had a sustained impact against the Fusarium graminearum. Among the prochloraz-loaded particles, small size prochloraz-loaded particles exhibited the best germicidal efficacy in two weeks. Besides, all prochloraz-loaded particles with different sizes hold the dose saving perforence.Keywords:  mPEG-PLGA; prochloraz; sustained release; size-dependent effect

Size-dependent effect of prochloraz-loaded mPEG-PLGA micro-and nanoparticles

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.