Bacterial quorum sensing relies on the recognition of signaling molecules as ligands for transcriptional activators, linking that signal with eventual gene expression.  This work focuses on understanding the specificity of protein-ligand interactions, and how different ligands may impact protein folding and DNA recognition.  The synthesis of a group of acylhomoserine lactone ligands and their interactions with the LasR transcription factor from the pathogenic Pseudomonas aeruginosa will be presented.

Characterization of regulator protein-ligand interactions in Gram-negative bacterial quorum sensing

248th National Meeting (2014)

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