The interactions between supported graphene sheets and biomolecules or cells are critical to sensing applications of graphene. Ongoing work focuses on the modification of graphene through chemical or physical modification.  These efforts are complicated by process-related defects and contamination of the graphene surface.  This work compares protein adsorption on graphene, glass, and plastic surfaces, with attention to adsorption kinetics, adsorbed amounts, and protein retention in flow.  The apparent extent of fibrinogen denaturing on graphene is compared to that on engineering and other model surfaces.  Additionally addressed is the ability of graphene to quench a fluorescent label on the adsorbed protein, compared with the fluorescence reduction of the tracer in the interfacial environment near glass, where local pH influences fluorescent yield.  Finally the adhesion of S. Aureus on graphene is compared with that on other model surfaces.  It is demonstrated how the processing of graphene sheets can influence graphene's bacteriocidal character.

Molecular and cell-level bio-adhesion to supported graphene sheets:  The fundamental basis for interactions

248th National Meeting (2014)

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