Alternatives to commonly used biocides, which cause unpredictable long-term environmental problems, are required. A biocide which can be deactivated after its application would be a tremendous progress to reduce the spread of microbial resistances.Here, biocidal Poly(2-methyloxazoline)s were prepared by introducing a biocidal and an antimicrobial inactivie satellite group (SG). The SG was chemically modified and this revealed a loss in antimicrobial activity. This hydrolysis was proven by 1H-NMR-spectroscopy and ESI-MS and the reduction of activity was followed by determining the minimal inhibitory concentration of the polymer. The hydrolysis of the satellite group and though the reduction of antimicrobial activity, was also performed under physiological conditions by enzymatic catalysis.

Bioswitchable antimicrobial poly(2-methyloxazoline)s

248th National Meeting (2014)

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