A major limitation to the success of current approaches for the fabrication of precisely-defined 3D tissue engineering scaffolds is the limited range of materials available for application with many commercially available materials being non-degradable. While some studies have reported developments to incorporate degradable polymers within such materials, they typically lack functional handles for orthogonal fabrication/functionalization and display a limited range of degradability profiles. We report the application of an allyl-functional aliphatic poly(carbonate) as the basis of a new resin for 3D microstereolithography. The application of radical thiol-ene chemistry in the presence of a biologically inert photo-inhibiting dye will be presented to demonstrate a range of versatile degradable and potentially renewable materials. Fabricated constructs and hydrogels from this material demonstrated good biological compatibility with cells and are proposed to provide excellent materials for a range of applications.

Fully degradable poly(carbonate) materials in microstereolithography

248th National Meeting (2014)

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