Current state-of-the-art liquid chromatography stationary phase materials are produced by bonding chloro- or methoxysilanes to surface hydroxyls of highly porous silica solid supports. These solution-phase depositions are time-consuming (4-150 hrs) and utilize toxic solvents to create stationary phases. A promising green and novel gas-phase deposition technique, coined Functionalized Carboxylate Deposition (FCD), was used to rapidly deposit a self-assembled monolayer of targeted a-carbon modified carboxylic acid containing small molecules to porous silica solid supports. The FCD process (15-30 min) produced novel stationary phases, without the use of toxic solvents, including a stationary phase coined: Halophase. Each of the Halophase compounds have shown different retentions based on their respective electronegativity and number (e.g. mono, di, or tri) of halogens, which should allow for specific tuning of retention characteristics and separations.

?Functionalized carboxylate deposition of Halophase compounds to create a novel stationary phase for efficient chromatographic separation

248th National Meeting (2014)

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