We revealed the strong surface-enhanced resonance Raman scattering (SERRS) effect of a novel nanoprobe, which was composed of graphene oxide (GO) and silver nanoshell for the sensitive detection of cancer cells. Silver nanoshell was prepared by amine-assisted reduction method, and then it was wrapped with 4,7,10-trioxa-1,13-tridecanediamine (TEG)-functionalized GO through electrostatic interaction (denoted �AgNS-GO�). The developed AgNS-GO nanoprobe exhibited beneficial properties in sensing including more intense and simpler Raman peaks than the ones of previous Raman nanoprobes, which allowed the simple and accurate recognition of targets at a glance. AgNS-GO was then successfully applied to SERRS-based detection and bioimaging of cancer cells.

Graphene oxide as a Raman label on ag nanoshells for surface-enhanced resonance Raman scattering-based detection of cancer cells

248th National Meeting (2014)

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