DNA-based chiral selectors were constructed via the specific interactions among metal ions, DNA and the drug enantiomers. Metal ions including Mg2+, Ni2+, Cu2+, Ag+ and Pt2+ are utilized to regulate the enantiomeric resolution through different coordination modes with DNA. For the chiral ofloxacin, DNA-Cu(II) complexes exhibit the highest enantioselectivities at the [Cu2+]/base ratio of 0.1, i.e., the enantiomeric excess can reach to 59% in R-enantiomer after being adsorbed by RET-Cu(II) complex. Through programming DNA sequences, the maximum S- and R-enantiomer adsorption capacities on the CuII-DNA complex can be increased. This work illustrates a novel promising route to construct DNA-based chiral selectors towards certain drug enantiomers through the programmable enantioselective recognition on the basis of DNA chirality and the specific binding of transition metal ions.

Enantioselective separation via DNA-based chiral selectors

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.