This paper describes conditions for C�H functionalization of tertiary aliphatic amines and their coupling with a number of 2-chloroazole derivatives and provides mechanistic insight. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to medicinally relevant a-azole carbinamines.

Photoredox-mediated C�H functionalization and coupling of tertiary aliphatic amines with 2-chloroazoles

248th National Meeting (2014)

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