The complexity of cells impedes elucidation of the mechanisms and properties of living systems. Consequently, there is a great need for the development of novel materials to enable the construction of synthetic vesicle cell models for use in the study of cell processes. To meet this need we have developed novel double hydrophilic block copolymers. Specifically, we have synthesized block copolymers from polysaccharides, poly(ethylene glycol), and polypeptoids. This was achieved modifying polymer chain ends to give hydroxy-amines with allowed us to take advantage of oxime chemistry to give high yielding and well defined materials. Additionally, we were able to access diblock copolymers by end-modifying dextran with amines to initiate polymerization of polypeptoids.  Because polysaccharides and synthetic polymers are both hydrophilic but not miscible with each other, we are able to readily create self-assembly structures. By varying the contents and molar masses of the blocks we are able to control the size of the self-assembly materials to reach both nano- and microsized structures. The relative mildness and ease of synthesis should allow us to meet the requirements of a synthetic cell or organelle: capable of diverse functionality, biocompatibility, and possessing selective membrane permeability.

Double hydrophilic block copolymers as cellular mimics

248th National Meeting (2014)

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