Figure: Reactor cavity with superimposed FLIR image of a microwave heated mixture in a borosilicate glass reactor.In a system which combines continuous flow and microwave heating1 we have been able to achieve good results in a broad variety of applications. New Pd(II)-catalyzed decarboxylative2 and desulfitative reactions have been adapted to continuous flow conditions with good results. We have demonstrated the use of a silicon carbide (SiC) reactor to avoid problems with hot-spot formation and subsequent reactor failure in Mizoroki-Heck and Suzuki-Miyaura reactions.3 We will also present on the synthesis of ionic liquids as well as the synthesis of gold nanoparticles in continuous flow.References:  1. �hrngren, P.; Fardost, A.; Russo, F.; Schanche, J.-S.; Fagrell, M.; Larhed, M. Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications. Org. Process Res. Dev., 2012  , 16(5), 1053�1063.  2. Rydfjord, J.; Svensson, F.; Trejos, A.; Sj�berg, P. J. R.; Sk�ld, C.; S�vmarker, J.; Odell, L. R.; Larhed, M. Decarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation., 2013  , Chem. Eur. J., 19(41), 13803�13810.  3. Konda, V.; Rydfjord, J.; Ver�n, J.-B.; S�vmarker, J.; Larhed, M. Manuscript

Continuous flow chemistry with a non-resonant microwave applicator

248th National Meeting (2014)

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