Carbon-carbon (C-C) bonds are ubiquitous but inert chemical bonds in most organic molecules, and they are seldom recognized as functional groups. Stimulated by the challenge of efficient synthesis of bridged/fused rings, we developed catalytic ketone/unsaturated moiety coupling reactions via C�C activation, which are complementary to the classical cycloadditions. This research is expected to provide a general and unified strategy to build complex skeletons, found in numerous natural products and drugs, from simple starting materials.

Catalytic c�c activation: A 'cut and sew' approach to bridged and fused rings

248th National Meeting (2014)

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