Nitrogen containing heterocyclic compounds such as Isoquinoline, Indole, and Pyridine derivatives are widely present in many natural products. Because the heteocyclic compounds provide structural backbone for pharmaceutical agents and organic materials, they have been in the center of attention in the organic synthetic community. In this project, Isoquinoline derivatives were produced via the coupling of benzophenone imines and alkynes in the presence of Rh(1) catalyst and DPEphos ligand. Working reactions were conditioned to occur in milder reaction condition and to provide improved yield. Significant ligand- and solvent effects on chemoselectivity and stereoselectivity have been observed. In this poster, preparation of Isoquinoline derivatives with different substituted functional groups will be presented.

Novel synthesis of Isoquinoline derivatives by Rhodium(I) catalyzed between N-H ketimines and internal alkynes

248th National Meeting (2014)

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