Substances containing decanal and trans-2-decenal have been touted to potentially possess anti-cancer properties. Since it has also been reported that chemical reactions involving biological and synthetic factors often form adducts with DNA, it has been proposed that the anti-cancer properties of decanal and trans-2-decenal may be due to the formation of adducts with DNA. The purpose of this research was to investigate the reactivity of decanal and trans-2-decenal toward nucleosides.  Reactions analyzed by 1H NMR, HPLC and UV spectroscopy were independently conducted between these aldehydes and guanosine, 2'-deoxyguanosine, 2'-deoxyadenosine, 2'-deoxycytidine, and thymidine. The impact of L-arginine in promoting these reactions was also evaluated.  Reaction results were compared with the hydrosylates of DNA which had been treated with decanal and trans-2-decenal.

Decanal and <i>trans</i>-2-decanal:  Investigation of nucleoside adduct formation

248th National Meeting (2014)

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Decanal and trans-2-decanal: Investigation of nucleoside adduct formation