It is believed that isoxazolines are an important component of some trial drugs used to protect against fungal, bacterial, and even HIV infections. In previous research it has been observed that isoxazolines have been synthesized from nitrile oxides and alkenes through a 1,3-dipolar cycloaddition. This product is biologically useful but these reactions typically involve significantly toxic reagents and/ or solvents. It is possible to synthesize isoxazolines with less toxic, more environmentally safe reagents; thus we are currently developing a greener method of high yield isoxazoline products via a one-pot synthesis reaction. To date, we have found that using 0.4 mmol SDS with 6.0 mmol bleach at 0 �C has given us yields similar to literature reactions that utilize toxic solvents.

Single pot synthesis of a biologically relevant compound in aqueous media

248th National Meeting (2014)

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