Protein design approaches, building on the pioneering work of Bill DeGrado and colleagues in the late nineteen eighties, have revealed many fundamental features of protein structure and stability. Moreover, we are now in the era that the early work presaged � the design of new proteins with practical applications and uses. In this talk I will briefly survey some past milestones, but mostly I will present the results of our most recent work. My talk will encompass first principles computational design, 'bioinfomatics' informed design, and design augmented by the use of in vivo selections and screens.

Protein design: Where have we been, where are we going?

248th National Meeting (2014)

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