Since the introduction of picloram to the herbicide market in the early 1960s, the discovery and development of pyridine carboxylic acid herbicides has been an active area of agrochemical interest. Accessing highly substituted picolinic acids has typically been accomplished starting from highly halogenated pyridine sources. The development of a new general method for the synthesis of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates starting from a non-pyridine source will be presented. This methodology does not require direct fluorination or metal assisted couplings, resulting in a cost effective and complementary approach to studying the structure activity relationship of pyridine carboxylic acid herbicides.

New methodology for the synthesis of picolinate herbicides

248th National Meeting (2014)

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