It is well known that the architectures (linear, branched, cyclic, and network) of polymeric materials dictate the physicochemical properties even though they have the same chemical compositions. Over the last decade, polymeric materials with excellent control over molecular weight, composition, structure, functionality, and conjugation have been made simpler with the development of unique synthetic such as controlled/living radical polymerizations (CLRPs) and click chemistry. Nanogel that is one of good drug carriers is composed of cross-linked structures by covalent bond, hydrophobic interaction, electrostatic interaction, and coordinate bond, which has been applied in biomaterial field for its high stability, high drug loading, and versatile incorporated materials such as molecules, peptides, proteins, nucleic acids, and inorganic particles. We found that a mixture of boroxole- and glyco-based polymers leads to form gel-construction (bulk and nanoparticles) due to the reversible boroxole-diol interaction. The boroxole group has received significant attention for its wide range of applications in catalysis for stereo-controlled synthesis, diagnosis, and medical treatment for human immunodeficiency virus (HIV), obesity, diabetes, and cancer. On the other hand, the glyco-based polymers of poly(3-gluconamidopropyl methacrylamide) (PGAPMA) and poly(2-lactobionamidoethyl methacrylamide) (PLAEMA) have been polymerized at different structures such as linear, hyper-branched, and conjugated nanoparticles for drug carries. Moreover, these glyco-based polymers were found to recognize a specific cell. In this study, we exploited a formation of gel by simple mixing of well-defined boroxole- and glyco-based polymers that were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The mixed gel and its nanoparticles are expected to apply in carriers for both diagnosis and therapy.

Interaction between boroxole- and glyco-based polymers for drug delivery system

248th National Meeting (2014)

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