Divergolides A-D and hygrocins A-F , novel ansmayicins i.e. deivatived of 3-amino-5-hydroxy benzoic acid (AHBA) derived polyketide natural products, hqave been shown to posess antibiotic and anticancer propoerties. We have been involved in synthesis of analogues of these families. We have screened the structural fragments and the synthetic intermediates to decipher if the SAR relations of this family in collaboration with Microbiotix. The results of our efforts will be shared.

Synthesis and evaluation of antibacetrial activity of of analogs of novel ansamycins- divergolides and hygrocins

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.