Argyrins are natural products that have antibacterial and anti-tumor activities. Their spectrum includes certain Gram negatives such as P. aeruginosa and B. multivorans. Our institute recently identified the cellular target of argyrin B as elongation factor G (EF-G), enabling further examination of the spectrum and resistance characteristics of these molecules. Here we present the medicinal chemistry optimization strategies employed on the Argyrin natural product template.

Optimization and activity of the argyrins for EF-G inhibition in gram negative pathogens

248th National Meeting (2014)

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