Nucleoside analogs are generally prepared by attaching an unnatural sugar to one of the natural nucleobases.  The development of new, unnatural nucleobases would expand the number of nucleoside analogs with potential biological activity.  1,2,3-triazole-4-carboxamide contains nearly all the functionality of purine nucleobases.  The preparation of a number of nucleosides constructed around this unnatural nucleobase will be reported.  Preliminary biological activity will also be disclosed.

1-Glycosyl-1,2,3-triazole-4-carboxamides as nucleoside analogs

248th National Meeting (2014)

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