Poly(2-oxazoline)s are an interesting class of polymers. Their properties can be tuned by varying the R group on the monomer and in this way functional groups can also be introduced. Methyl ester functionalized side chains are especially interesting as it can be hydrolysed to the carboxylic acid, a versatile functionality for conjugation of peptides and proteins. Moreover, the methyl ester group can undergo a transamidation reaction to easily introduce a wide variety of side chain amide moieties. Even though the synthesis and copolymerization of 2-methoxycarbonylethyl-2-oxazoline has been reported, the (co)polymerization kinetics are yet unknown. In this poster we present detailed studies on the homo- and copolymerisation kinetics of two methyl ester functionalized 2-oxazoline monomers with 2-methyl-2-oxazoline, 2-ethyl-2-oxazoline and 2-n-propyl-2-oxazoline, unexpectedly revealing that the methyl ester containing monomers significantly accelerate the polymerization.

Synthesis of poly(2-oxazoline)s with side chain methyl ester functionalities

248th National Meeting (2014)

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