Most pharmaceutical companies discover and develop chemical compounds as therapeutic agents. Techniques relating to chemical compound searching will be discussed in this presentation. For purposes of patentability and freedom to operate, various approaches can be used in searching for chemical compounds. If compounds are small molecules, a structure search in CAS REGISTRYSM is a good starting point. CAplusSM is the companion reference database to CAS REGISTRY which includes both patent and non-patent records. Chemical compounds can also be searched by name (such as a trade name), by chemical name and by a descriptor based on activity, in addition to other methods. MARPAT� can be searched to find patent references where the compounds fall within a Markush structure. Reactions or methods to synthesize the compounds can be searched in the CAS reaction database, CASREACT�. STN� hosts a broad collection of leading scientific and technical databases which can be searched individually or simultaneously.

Considerations in chemical compound searching

248th National Meeting (2014)

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