While nitrogen heterocycles form the core of a large percentage of small molecule pharmaceuticals, the number of different heterocyclic systems used for this purpose is small.  For this reason, intellectual property space around these commonly used heterocycles has become crowded through decades of pharmaceutical research.  The discovery of new synthetic routes to previously unreported heterocycles will possibly facilitate the discovery of new drugs while minimizing intellectual property overlap.  Toward this end, we will present general synthetic routes for the preparation of functionalized and previously unknown nitrogen heterocycles.

New heterocyclic scaffolds for drug discovery

248th National Meeting (2014)

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