Antiestrogens, SERMs, Aromatase and 17-�HSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of brest tumers. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles were synthesised and charactrarized by IR,1H NMR, 13c NMR spectroscopy and elemantal analysis. This Flavone derivatives were found to exhibit good IC50 value against different cell lines like MCF-7, SNB-75 and others.  

Synthesis of new flavone derivatives against estrogen dependent cancers

248th National Meeting (2014)

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