Sterol-biosynthesis inhibitors, especially the sterol demethylation inhibitors (DMIs), are an important group of agricultural, industrial and clinical fungicides. The target site of the DMIs is the cytochrome P450 CYP51. While some cases of DMI resistance have been reported due to non-target-site mechanisms such as enhanced efflux, most cases of reduced DMI sensitivity are due to mutations or over-expression of CYP51.  In the wheat pathogen Zymoseptoria tritici, over 30 CYP51 mutations have been reported, in over 60 combinations, conferring a range of sensitivity levels to different DMI fungicides. We discuss the evolutionary pathways and functional constraints leading to these various genotypes, and the implications for disease control and resistance management.

Sterol biosynthesis inhibitors: Modes of resistance and development of <i>CYP51</i> mutations

248th National Meeting (2014)

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Sterol biosynthesis inhibitors: Modes of resistance and development of CYP51 mutations