S-Nitrosothiols exhibit biological activity, eg, vasodilators, due to its ability to transport and release of NO. UV and infrared specific spectroscopic properties explain their conformation and stability, which are essential to their potential activity.In this study, some mecapto-N-arylamides (I) and their S-nitrosothiols derivatives (II) were synthesized. Their optical properties were obtained by using the Z-Scan technique, which is widely used to study the materials nonlinearity. We observed that the compounds thermal diffusivity is sensitive to their molecular conformation. The corresponding thiol and its derivative S-nitrosothiol showed different conformations and larger discrepant diffusivity values. The optical nonlinear refractive index of the S-nitrosothiol is higher than the correspondent thiol, regardless the molecular conformation. Analyzing both classes of compounds we conclude that the NO group is responsible for the changes in the optical nonlinear refractive index.                                                                                                                

Nonlinear optical study of  mercapto-<i>N</i>-arylbutanamides and <i>S</i>-nitrosothiols derivatives to determine conformational stability

248th National Meeting (2014)

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Nonlinear optical study of mercapto-N-arylbutanamides and S-nitrosothiols derivatives to determine conformational stability