Developing a general protocol in which large sets of molecules are synthesized simultaneously is an efficient way to build structure activity relationships (SARs). The preparation of several libraries around a modest wheat leaf rust (Puccinia triticina) screening hit (Compound 1) lead to the discovery of a novel substituted pyrimidine with excellent wheat leaf blotch (Septoria tritici) activity. The method involved sequential displacements at the 4 and 2-positions of a substituted pyrimidine ring. After treatment with scavenger resins, the products were sufficiently pure for biological testing. Over 400 analogs were assembled and the resulting three dimensional array allowed rapid assessment of fungicidal trends and the identification of a particularly efficacious molecule. The LC50 of this new compound was well below 6 ppm in both protectant and curative applications. Synthesis and biological activity will be discussed in this presentation.

Combinatorial approach to lead generation and the discovery of a novel agent for <i>Septoria tritici</i> control

248th National Meeting (2014)

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Combinatorial approach to lead generation and the discovery of a novel agent for Septoria tritici control