Minimizing nonspecific interactions of nanoparticles with natural and engineered interfaces is an essential prerequisite to the design of specific interactions or targeting applications. If their surfaces cannot be masked efficiently, nanoparticles tend to agglomerate, adhere, or precipitate prematurely. Typical strategies for maintaining nanoparticle stability in vitro or in vivo employ neutral polymers or oligomers physically or chemically bound to the surface. For example, oligomeric or polymeric ethylene glycol (PEG) endows stability and enhances circulation times. We have developed a monomeric sulfobetaine zwitterion motif for decorating nanoparticle surfaces. These small, water-soluble reagents have been chemically attached to the surfaces of gold, silica and iron oxide nanoparticles using thiol or siloxane chemistry. The protected nanoparticles are highly stable when challenged with salt or proteins. We will describe the synthesis and properties of these nanomaterials, and we will explore the fundamental science behind the excellent nonfouling properties of the zwitterion surface.

Minimizing nonspecific nanoparticle interactions via zwitteration

248th National Meeting (2014)

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