Several molecular imaging modalities have focused on imaging agents that are chemically modified in the tumor microenvironment, for example 18F-FMISO, which is accumulated in hypoxic cells by an O2-dependent mechanism. Our work has focused on the development of a prodrug scaffold to interrogate tumor microenvironments, for example the low pH found in the extracellular matrix, and increased concentrations of reactive oxygen species (ROS) in particular H202. We have synthesized several 18F hydrazones and oximes as imaging prodrugs from their corresponding hydrazine and hydroxylamine precursors, at high radiochemical yield. These have shown to be responsive to chemical microenvironment in vitro.

FDG-based prodrugs for imaging chemical microenvironment

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.