Aminopropenoates are a new class of fungicides especially active against oomycetes pathogens. This family exhibits many interesting features such as a new but yet unknown mode of action and demonstrated efficacy against strains resistant to market standards. A fragment-oriented chemistry was developed allowing a rapid modification of the main subunits. This allowed the determination of SAR in short time. Optimization of the original lead structure demonstrated a good potential of the family at low dose rates on downy mildews such as Plasmopara viticola or Peronospora bracicae and tomato late blight Phytophtora infestans.

Aminopropenoates: A new class of fungicides against oomycetes

248th National Meeting (2014)

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