Mollisin (1  ), a promising antifungal natural product, was first isolated by Gremmen in 1956 from several mollisia species. Its structure was elucidated in 1964 by Overeem and first tests revealed both antibiotic and antifungal properties. The biosynthesis of mollisin by the fungus Mollisia caesia proceeds via the polyketide pathway and the chlorine atoms are introduced with the aid of chloroperoxidase. Recently, the first total synthesis of mollisin could be achieved which enables access to larger amounts of this bioactive secondary metabolite and, more importantly, paves the way to a wide range of promising derivatives.

Mollisin: A promising antifungal natural product

248th National Meeting (2014)

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