Tobacco mosaic virus (TMV) infection is very widely distributed and can cause serious damage and large economic loss, further research needs to be conducted in this area for the development of a highly ef?cient, novel, environmentally benign antiviral agent. Considering that a-terthienyl's phototoxic activity against a great number of organisms including bacteria, fungi, viruses, nematodes, tumor cell and larvae of insects, a series of a-terthienyl derivatives were designed and synthesized. The preliminary bioassay results showed that compounds of formula 1 have good anti-TMV activity in vivo (inactivation activity, 48.7%/500 �g.mL-1 and protection activity, 45.6%/500 �g.mL-1) with higher antiviral activity than Ribavirin, but lower than Ningnanmycin. These compounds have emerged as a potential inhibitors of the plant virus and have great potential for further development as tobacco protection agents.

Design, synthesis, and anti-tobacco mosaic virus activity of novel a-terthienyl derivatives

248th National Meeting (2014)

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