A series of trans-3-aryl acrylic acids and their derivatives were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which several compounds exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structures than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and can be considered as a novel therapy against plant virus infection.

Discovery and SAR of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents

248th National Meeting (2014)

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