Benzisothiazolinone (BIT) is widely used as an active preservative ingredient in emulsion paints and home cleaning products. However, BIT was reported to be harmful to human and aquatic environment. According to a material safety data sheet, acute toxicity to rat is 1.020 mg/kg (LD50 oral) and toxicity to Oncorhynchus mykiss is 0.8 mg/l � 96.0 h (LC50). In this regard, the development of qualitative and quantitative analysis methods of BIT is important. Surface-Enhanced Raman Spectroscopy (SERS) is a powerful method to analyze and identify samples rapidly because of its high sensitivity and molecular fingerprinting character. In this study, we conducted SERS study to quantify BIT with the help of aggregated silver nanoparticles. We could acquire reproducible concentration dependent Raman spectra with the detection limit of 200 ppb. The results imply that SERS can provide a new strategy for the qualitative and quantitative analysis of other biocides.

Analysis of antibacterial benzisothiazolinone using surface-enhanced Raman spectroscopy

248th National Meeting (2014)

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