Mononuclear aluminum schiff base compounds of the type salen(tBu)AlBr can dealkylate a wide range of organophosphate compounds. In these reactions the resulting product is a compound where the dealkylated phosphate ester is covalently bound to the aluminum through a hydrolytically stable Al-O-P linkage. These reactions lead to unique organic-soluble aluminum phosphate compounds containing six-coordinate aluminum. Also in collaboration with Edgewood Chemical Biological center we have developed ESI-MS technique for detection of nerve agents. Salen(tBu)Al acetate, obtained by combination of salen(tBu)AlBr and NaAc, form Lewis acid base adducts with nerve agents and other organophosphate compounds. These adducts are sufficiently stable to allow detection of nerve agent by ESI/MS. This adducts give distinctive mass spectrometry signatures and the molecular ion peak was detected for adduct with GB, GD, and VX hydrolysis product, EMPA.

Organophosphate dealkylation and detection with salen aluminum chelates

248th National Meeting (2014)

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