A novel triblock and H-shape macromolecular architecture based on cyclodextrin (CD) complexation is presented.Doubly guest-containing poly(N,N-dimethylacrylamide) (PDMA) (6400 = Mn = 15700 g�mol-1;1.06 = �M = 1.15) and poly(N,N-diethylacrylamide) (PDEA) (5400 = Mn = 12100 g�mol-1;1.11 = �M = 1.33), CD-functionalized biocompatible poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) (3800 = Mn = 10600 g�mol-1;1.29 = �M = 1.46) and mid-chain CD functionalized PDMA and PDEA (10200 = Mn = 11100 g�mol-1;1.26 = �M = 1.30) segments were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization and copper catalyzed azide alkyne cycloaddition. The building blocks were subsequently utilized for the formation of a supramolecular ABA triblock and H-shape copolymers. The formation was evidenced via dynamic light scattering (DLS), nuclear Overhauser enhancement spectroscopy (NOESY) and turbidity measurements. Furthermore, the connection of the blocks was proven to be temperature responsive and � in the case of azobenzene guests � responsive to the irradiation with UV-light. In the case of PDEA containing complexes, the temperature induced aggregation was investigated as well.

Multi responsive macromolecular linear and H-shape architectures via cyclodextrin host/guest chemistry

248th National Meeting (2014)

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