Recently enormous efforts have been spend to advance polymer synthesis methods, enabling monomer sequence control.1,2, 3 Methods of controlled radical polymerization played one major role to precisely position functionalities in synthetic polymers.4 After principles of advanced synthesis routes have been established, one of the upcoming challenges will be finding applicable sequences to demonstrate the potentials of fully synthetic polymers, which exhibit a defined monomer sequence. Here we summarize recent advances and present our approach to extract interesting minimal sequences from biological sources to design precision polymers. Those polymers mimic aspects of functional biomacromolecules with non-biological monomer building blocks and might enlarge the functional space available for polymers useful for drug delivery,5 adhesives6 or nanoengineering of surfaces.7 Figure. Extracting minimal sequences from biological macromolecules to be mimicked with fully synthetic precision polymers. 1. B�rner, H. G. Macromol. Rapid Commun. 2011  , 32, 115.2. B�rner, H. G. Prog. Polym. Sci. 2009  , 34, 811.3. Lutz, J. F.; Ouchi, M.; Liu, D. R.; Sawamoto, M. Science 2013  , 341, 628.4. Baradel, N.; Fort, S.; Halila, S.; Badi, N.; Lutz, J. F. Angew. Chem.-Int. Edit. 2013  , 52, 2335.5. Wieczorek, S.; Krause, E.; Hackbarth, S.; R�der, B.; Hirsch, A. K. H.; B�rner, G. H. J. Am. Chem. Soc. 2013 , 1711-1714.6. Wilke, P.; B�rner, H. G. ACS Macro Lett. 2012  , 1, 871-875.7. Schwemmer, T.; Baumgartner, J.; Faivre, D.; B�rner, H. G. J. Am. Chem. Soc. 2012  , 134, 2385.

Using CRP to translate bioinspired sequences toward synthetic polymers to explore sequence specific interactions

248th National Meeting (2014)

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