High-throughput screening (HTS) is an effective tool in early stage discovery research. The use of these screens at Dow AgroSciences (DAS) led to the discovery of insect active analogs 1  and 2.   Originally prepared as part of a herbicidal effort, results from high-throughput screening indicated that the insecticidal activity these analogs exhibited was far more intriguing. A retrospective analysis of similar compounds prepared in-house led to the discovery of an older set of insecticidal pyridazine analogs (3 ). The similarity in structure to compounds 1  and 2  prompted further investigation into the structure activity relationship (SAR) around this chemistry which will be described in this talk.

High-throughput screening (HTS) enabling the discovery of an insect active from a herbicide hit

248th National Meeting (2014)

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