Based on the comparative metabolism of oxathiapiprolin in primary and rotated crops, oxathiapiprolin and seven metabolites were included in the working residue definition (analytical methods development) for raw and processed plant commodities. Supervised field trials were conducted to build an understanding of the crop residue profile in treated crops following foliar and soil applications, in rotated crops and in processed commodities. In conclusion, oxathiapiprolin is the main residue in crop commodities. Four metabolites IN-Q7H09, IN-RDG40, IN-RZB20, and IN-RZD74 are never/rarely quantifiable. Three metabolites IN-E8S72, IN-SXS67 and IN-WR791 are quantifiable in more than 5% of the samples. The magnitude and decline of residue data for oxathiapiprolin and metabolites generated in the supervised field trials are sufficient to conduct risk assessments, define the residues and set MRLs. Based on low livestock dietary burdens and low transfer of residues from feed to edible commodities in the hen and goat metabolism studies, oxathiapiprolin and metabolite residues are estimated as <0.01 mg/kg in meat, tissues, milk or eggs as a result of eating feed items containing oxathiapiprolin residues. Poultry and cattle feeding studies were not conducted.

Magnitude and decline of oxathiapiprolin (DuPont� Zorvec�) and metabolite residues in crop commodities: Inputs for consumer risk assessment and MRL setting

248th National Meeting (2014)

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