Exposure to the non-caloric constituents of the human diet is one of the major ways by which the environment influences the expression of genes as well as alters homeostatic regulations. One of the major groups of these non-caloric food components are phenolic and polyphenolic compounds. These compounds have been associated with several biological processes and pathways; however, there is very limited understanding of their mode(s) of action and/or their molecular target(s). Using cheminfomatics, structural biology and modeling tools, we have made some predictions on the molecular targets of some dietary polyphenols. These predictions have been tested experimentally, and the results of this work will be presented.

Using cheminfomatics to decipher the molecular targets of dietary polyphenols

248th National Meeting (2014)

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