For pharmaceutical applications such as oral controlled drug delivery systems, Hydroxypropyl methylcellulose (HPMC) is a promising raw material for coatings or films obtained from aqueous systems.Additives are incorporated into biopolymer matrices to produce high quality drug protective films.The aim of this work is to explore their bulk and surface properties [1]. The influence of additives on HPMC structuration and morphology, permeation, hydrophilic or hydrophobic character as well as surface adhesion and friction are evaluated at nanoscale. Stearic acid additive has a strong influence on HPMC surface properties and morphology due to microphase separation and surface migration of stearic acid molecules. A sharp variation of nano-adhesion and nano-friction forces is observed with addition of fatty acid and thus even for low additive content 1% (w/w HPMC). PEG additives induce an increase of the surface hydrophilicity and affect HPMC morphology by insertion mechanisms. Swelling of HPMC clusters is observed as PEG content increases.At the nanoscale, the increase of PEG content causes an increase of friction and adhesion forces.Results underline the strong dependence of surface film properties with additive nature and concentration. formulation is then an original way to tune surface morphology and properties of biopolymer films.[1] M. Brogly, A. Fahs, S. Bistac, In Nanaoscience and Technology, Scanning Probe Microscopy in Nanoscience and Nanotechnology, B.Bhushan Ed., Springer (2011) 473

Nanosurface properties of biopolymer coatings used for oral drug delivery

248th National Meeting (2014)

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