Axially chiral aminophosphines 1  with t-butyl group were obtained in good yields by SNAr reaction of the corresponding phosphine oxides and N-methylation followed by silane reduction.  Optical resolution of C(aryl)-N(amine) bond atropisomers of acyclic amines 1  were described. Finally, the ability of the chiral amines 1  as ligands is demonstrated in catalytic asymmetric reaction such as a palladium-catalyzed asymmetric allylic alkylation (up to 95% ee).

Synthesis and application of axially chiral aminophosphines with <i>t</i>-butyl group

248th National Meeting (2014)

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Synthesis and application of axially chiral aminophosphines with t-butyl group